Faculty Focus - Taufik Valiante


Taufik Valiante, MD, PhD, FRCSC Valiante T_Fall 2011

Dr. Valiante graduated from the MD/PhD program at the University of Toronto in 1997, with doctoral studies completed under the supervision of Dr. Peter Carlen at Toronto Western Research Institute.  In that year he began his residency in the Neurosurgery Training Program at the University of Toronto, and he became a Fellow of the Royal College of Physicians and Surgeons of Canada in 2003.  Dr. Valiante then pursued an epilepsy neurosurgery fellowship at the University of Washington, Seattle, under the mentorship of Dr George Ojemann. There, he learned Dr Ojemann's technique of language mapping for patient's undergoing epilepsy surgery. In 2003, Dr. Valiante was recruited back to the University of Toronto as an Assistant Professor and, as a CIHR Clinician-Scientist, he launched his research program in the field of electrophysiologal characterization of neuronal networks in epilepsy. His neurosurgical staff appointment is at the Toronto Western Hospital with a practice in adult epilepsy surgery. He currently serves as Co-Director of the Epilepsy Program at the Krembil Neuroscience Centre, University Health Network and is appointed as an Associate Member of the Institute of Medical Science at the University of Toronto.

Current Appointments

  • Co-Director, Epilepsy Program, Krembil Neuroscience Centre, University Health Network
  • Associate Professor of Surgery, Faculty of Medicine, University of Toronto
  • Associate Member, Institute of Medical Science, University of Toronto

Recent Selected Peer-Reviewed Funding

  • Ontario Brain Institute (OBI), 2013-2018
    Cerebrovascular reactivity (CVR) in patients with mesial temporal lobe epilepsy (mTLE)
    PI: Valiante T; Co-I's: Carlen PL, Bardakjian BL.
    $250,000
  • Ontario Brain Institute (OBI), 2013-2018
    Optical control of state transitions in epileptogenic cortex. 
    PI: Valiante T; Co-I's: Carlen PL, Bardakjian BL.
    $250,000
  • Canadian Institutes of Health Research (CIHR), 2012-2017.
    Transitional states of seizures: mechanisms and modulation.
    PI: Carlen P;  Co-I: Valiante T.
    $705,670
  • Canadian Institutes of Health Research (CIHR), 2009-2012.
    Spatial and temporal characterization of hippocampal memory processes: studies in the normal brain and individuals with medial temporal-lobe epilepsy and excisions.
    Co-PI's: Valiante T, McAndrews MP; Collaborators: Cohn M, Protzner AB.
    $712,092
  • Mathematics of Information Technology and Complex Systems (MITACS)-Accelerate Cluster Award, 2011-2012.
    Signal processing of EEG for detection and classification of clinical brain states.
    PI: Valiante T; Co-I's: Bardakjian B, Carlen P.
    $60,000

Selected Distinctions and Awards

  • Canadian Institutes of Health Research (CIHR) Clinician-Scientist Award, Phase 1, 2003-2006
  • Alan R. Hudson Faculty Teaching Award, Division of Neurosurgery, University of Toronto, 2006
  • Ross Fleming Surgical Educator Award for Excellence in Undergraduate or Postgraduate Teaching, Department of Surgery, University of Toronto, 2006
  • William J. Horsey Prize for Clinical Research, 1st Place, Division of Neurosurgery, University of Toronto, 2002

Selected Peer-Reviewed Publications

  • Womelsdorf T, Valiante TA, Sahin NT, Miller KJ & Tiesinga P. Dynamic Circuit Motifs underlying Rhythmic Gain Control, Gating and Integration. Nature Neuroscience. 2014 Aug 17;17(8). 
  • Hoffman KL, Dragan MC, Leonard TK, Micheli C, Siegmund RM, and Valiante TA. Saccades during visual exploration align hippocampal 3-8 Hz rhythms in human and non-human primates. Frontiers in System Neuroscience. 2013 Aug 30;7:43.  
  • Fallah A, Raghavan LV, Valiante TA. Wearable video display allowing freedom in head positioning for brain mapping. Can J Neurol Sci. 2013 Jan;40(1):106-8.
  • Mansouri A, Fallah A, Valiante TA. Determining surgical candidacy in temporal lobe epilepsy. Epilepsy Res Treat. 2012;2012:706917.
  • Serletis D, Bardakjian BL, Valiante TA, Carlen PL. Complexity and multifractality of neuronal noise in mouse and human hippocampal epileptiform dynamics. J Neural Eng. 2012 Oct;9(5):056008.
  • Guha D, Kiehl TR, Krings T, Valiante TA. Intracerebral schwannoma presenting as classic temporal lobe epilepsy. J Neurosurg. 2012 Jul;117(1):136-40.
  • Zhang ZJ, Koifman J, Shin DS, Ye H, Florez CM, Zhang L, Valiante TA, Carlen PL. Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region. J Neurosci. 2012 Feb 15;32(7):2499-512.
  • Cotic M, Zalay O, Valiante T, Carlen PL, Bardakjian BL. Frequency interactions in human epileptic brain. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2057-60.
  • Zhang ZJ, Valiante TA, Carlen PL. Transition to seizure: from "macro"- to "micro"-mysteries. Epilepsy Res. 2011 Dec;97(3):290-9.
  • Serletis D, Zalay OC, Valiante TA, Bardakjian BL, Carlen PL. Complexity in neuronal noise depends on network interconnectivity. Ann Biomed Eng. 2011 Jun;39(6):1768-78.
  • Howe KL, Dimitri D, Heyn C, Kiehl TR, Mikulis D, Valiante T. Histologically confirmed hippocampal structural features revealed by 3T MR imaging: potential to increase diagnostic specificity of mesial temporal sclerosis. AJNR Am J Neuroradiol. 2010 Oct;31(9):1682-9.

Selected Professional Activities

  • Member, Integrated Epilepsy Care Committee, Epilepsy Ontario, 2006-present.
  • Executive Member, Board, Epilepsy Toronto, 2004-present.
  • Member, Program in Neuroscience Distinguished Lecturers Selection Committee, Faculty of Medicine, University of Toronto, 2009-present.
  • Provincial Epilepsy Strategy Expert Group, Toronto, 2013-present.